This course provides a comprehensive update on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), reframing it as a critical multi-system metabolic disorder rather than an isolated hepatic condition. Clinicians will explore the pathophysiology linking hepatic fat accumulation, lipotoxicity, and insulin resistance, alongside modern non-invasive diagnostic tools like FIB-4 scoring and FibroScan. The curriculum emphasizes the early identification of extra-hepatic complications, particularly cardiovascular and renal risks, and reviews contemporary lifestyle and pharmacological interventions designed to halt disease progression.