Treating Heart Failure with reduced Ejection Fraction has moved far beyond basic diuresis. This course offers a clear guide to the four pillars of therapy that are currently redefining patient survival. We examine how to transition from traditional blocks to modern, high-impact treatments like ARNIs and SGLT2 inhibitors. You will learn to navigate the practical challenges of initiation and titration while focusing on the long-term goal of reducing cardiovascular death and keeping patients out of the hospital.