This course establishes obesity as a complex, chronic, and relapsing disease that requires long-term medical strategy rather than acute lifestyle prescriptions. Participants will analyze the central nervous system regulation of energy homeostasis and the body’s metabolic adaptations to weight loss. The curriculum compares the mechanisms, efficacy, and safety profiles of contemporary anti-obesity medications and bariatric interventions, while encouraging a person-first clinical framework to improve patient adherence and long-term outcomes.