This course brings together global perspectives on advancing heart failure (HF) care in the context of comorbidities, exploring how interconnected care models are reshaping outcomes for patients with complex needs. Participants will examine the latest evidence and innovations in managing HF alongside common comorbidities such as diabetes, chronic kidney disease, obesity, and hypertension. Through discussions on multidisciplinary collaboration, digital health integration, and patient-centered strategies, the course provides actionable insights into tailoring therapies, improving adherence, and reducing hospitalization risks. Designed as a global forum, it highlights best practices and emerging approaches to deliver truly connected, comorbidity-specific HF care.