This focused session provides a critical appraisal of the most impactful research in interventional and device cardiology presented at ESC 2025. We will analyze late-breaking clinical trials on structural heart interventions (TAVI/MitraClip), advanced antiplatelet regimens for complex PCI, and the latest evidence guiding ICD and CRT utilization. Understand the European perspective on integrating physiological and intravascular imaging, and refine your procedural protocols based on the year’s most important findings.